Anti -C1s Rabbit pAb

價格：在線咨詢

貨號：

DRF101926

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	C1s rabbit polyclonal
Protein full name	Complement C1s-A subcomponent
Synonyms	C1 esterase, Complement component 1 subcomponent s-A, C1sa, C1s
Immunogen	Recombinant protein corresponding to Mouse C1s
Isotype	IgG
Purity	Affinity purification
Predicted MW.	77 kDa
Observed MW.	80 kDa

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse	1: 500-1: 1000	kidney, liver

Background

The complement component proteins, C1, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the classical pathway of the serum complement system. C1 consists of a calcium dependent trimolecular complex of C1r, C1s and C1q. Activated C1s is in the form of a disulfide-linked heterodimer consisting of a heavy chain and a light chain. Defects in the gene encoding for C1s can cause selective C1s deficiency, a disorder characterized by early onset of various autoimmune diseases.

Images

Western blot analysis of C1s
at dilution of 1: 1000
Lane 1: Mouse kidney tissue lysate
Lane 2: Mouse liver tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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