Anti -AMPK gamma 1 Rabbit pAb

價格：在線咨詢

貨號：

KT012266

產(chǎn)品規(guī)格：

100ul

Applications：

Species：

M/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	AMPK gamma 1 rabbit polyclonal antibody
Protein full name	5'-AMP-activated protein kinase subunit gamma-1
Synonyms	AMPK gamma1, AMPK subunit gamma-1, AMPKg, Prkag1, Prkaac
Immunogen	Recombinant protein corresponding to Mouse AMPK gamma 1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	38 kDa
Observed MW.	38 kDa
Uniprot ID	O54950, P80385

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	heart, brain, muscle

Background

AMP/ATP-binding subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.

Images

Picture 1.png

Western blot analysis of AMPK-γ1at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

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