Anti -LAT Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT012279

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M/R,H/M/R,H/M/R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	LAT rabbit polyclonal antibody
Protein full name	Linker for activation of T-cells family member 1
Synonyms	36 kDa phospho-tyrosine adapter protein, pp36, p36-38, Lat
Immunogen	Recombinant protein corresponding to Mouse LAT
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane
Predicted MW.	26 kDa
Observed MW.	38 kDa
Uniprot ID	O54957, O70601

Applications

Applications	Species	Dilution	Positive Sample
WB	Mouse, Rat	1: 500-1: 1000	spleen, thymus, lymph
IHC/IF	Human, Mouse, Rat	1: 500-1: 4000	colon, thymus

Background

Linker for activation of T-cells family member 1 (LAT) is a single-pass type III membrane protein which is required for TCR (T-cell antigen receptor) and pre-TCR-mediated signaling, both in mature T-cells and during their development This protein is involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Functionally T cell receptor (TCR) activation results in tyrosine phosphorylation of LAT, leading to the direct interaction with several proteins, including PLC-gamma 1, Grb2 and Gads.

Images

	Western blot analysis of Lat at dilution of 1: 500
	Immunohistochemistry of paraffin embedded mouse thymus using Lat (GB111123) at dilution of 1: 2000 (400x lens)
	Immunohistochemistry of paraffin embedded rat thymus using Lat (GB111123) at dilution of 1: 2000 (400x lens)
	Immunofluorescence of paraffin embedded human colon using Lat (GB111123) at dilution of 1: 2100 (400x lens)
	Immunofluorescence of paraffin embedded mouse thymus using Lat (GB111123) at dilution of 1: 2100 (400x lens)
	Immunofluorescence of paraffin embedded rat colon using Lat (GB111123) at dilution of 1: 2100 (400x lens)
	Immunofluorescence of paraffin embedded rat thymus using Lat (GB111123) at dilution of 1: 2100 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

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