Anti -MAML1 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT012282

產(chǎn)品規(guī)格：

100ul

Applications：

Species：

H/M

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	MAML1 rabbit polyclonal antibody
Protein full name	Mastermind-like protein 1
Synonyms	Mam-1, Maml1, Kiaa0200, Mastermind like 1
Immunogen	Recombinant protein corresponding to Mouse MAML1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	108 kDa
Observed MW.	130 kDa
Uniprot ID	Q92585, Q6T264

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse	1: 500-1: 1000	lung, thymus

Background

MAML1, also named as KIAA0200 and Mam-1 , belongs to the mastermind family. It acts as a transcriptional coactivator for NOTCH proteins. MAML1 has been shown to amplify NOTCH-induced transcription of HES1. It enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. MAML1 binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. It plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions. The calculated molecular weight of MAML1 is 108 kDa, but modified MAML1 is about 120-130 kDa.

Images

Picture 1.png

Western blot analysis of maml1 at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

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