Anti -NOTCH3 Rabbit pAb

價格：在線咨詢

貨號：

KT011235

產(chǎn)品規(guī)格：

100ul

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	NOTCH3 rabbit polyclonal antibody
Protein full name	Neurogenic locus notch homolog protein 3
Synonyms	Notch 3, NOTCH3, Notch 3 extracellular truncation, Notch 3 intracellular domain, CADASIL, CASIL
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse NOTCH3
Isotype	IgG
Purity	Affinity purification
Predicted MW.	244 kDa
Observed MW.	110 kDa (cleaved)
Uniprot ID	Q9UM47

Applications

Applications	Species	Dilution	Positive Sample
WB	Human	1: 100-1: 500	HeLa, MCF-7, K562

Background

NOTCH3 belongs to the NOTCH family. It functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. NOTCH3 affects the implementation of differentiation, proliferation and apoptotic programs. Defects in NOTCH3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Images

Picture 1.png

Western blot analysis of Notch3 at dilution of 1: 100

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

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